This service provides a graphical report of several important structural characteristics of the PDB entry. It offers a plot from PDB cartoon annotated with color coded scales representing for each amino acid the corresponding temperature factor, solvent accessibility of the chain in isolation and in complex with the other present chains in PDB file, sequence conservation in a multiple alignment (relative sequence entropy) and histograms representing the atomic contacts (as in the Graphical contacts module), as well as IFR residue identification and IFR contacts. In addition, comparison of the Secondary Structure annotated by PDB and by DSSP is presented.
Protein Dossier is an excellent tool to browse through valuable information about the protein chain. Collection of information is allowing the user to make very knowledgeable decisions about possible role of specific amino acid (or number of them) in defining the function. It also helps in deciphering what effect the specific mutation will have on the structure and function of the protein.